Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?
Identifieur interne : 000330 ( Main/Exploration ); précédent : 000329; suivant : 000331Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?
Auteurs : Daniel Batlle [États-Unis] ; Jan Wysocki [États-Unis] ; Karla Satchell [États-Unis]Source :
- Clinical science (London, England : 1979) [ 1470-8736 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux, Attachement viral, Haplorhini, Humains, Infections à coronavirus (traitement médicamenteux), Lignée cellulaire, Peptidyl-Dipeptidase A (physiologie), Pneumopathie virale (traitement médicamenteux), Protéines recombinantes (usage thérapeutique), Réplication virale, Solubilité, Virus du SRAS (pathogénicité).
- MESH :
- pathogénicité : Virus du SRAS.
- physiologie : Peptidyl-Dipeptidase A.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Protéines recombinantes.
- Animaux, Attachement viral, Haplorhini, Humains, Lignée cellulaire, Réplication virale, Solubilité.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Peptidyl-Dipeptidase A.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- pathogenicity : Betacoronavirus, SARS Virus.
- chemical , therapeutic use : Recombinant Proteins.
- Animals, Cell Line, Haplorhini, Humans, Solubility, Virus Attachment, Virus Replication.
Abstract
A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy.
DOI: 10.1042/CS20200163
PubMed: 32167153
Affiliations:
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This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. 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